About Lynch Syndrome
What are the cancer risks for people with Lynch Syndrome?
- A higher than usual risk of developing colorectal cancer (20-80% lifetime risk). These
cancers tend to occur before the age of 50. See Figure 1.
- An increased risk of developing a second primary colorectal cancer.
- Women have a 15-60% lifetime risk of developing endometrial cancer.
Other cancers that occur less commonly in Lynch syndrome include: ovarian, stomach, urinary
tract, hepatobiliary tract (part of the liver and bile ducts), small intestine, pancreas, skin (sebaceous gland tumors) and brain.
People with Lynch syndrome who have sebaceous gland skin tumors are often referred to as having the Muir-Torre variant of Lynch syndrome. The sebaceous tumors include: sebaceous adenomas, sebaceous carcinomas, epitheliomas and keratoacanthomas.
Cancer risk can be reduced by following cancer screening and prevention guidelines.
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